Cleveland Clinic, when it was founded in 1921 as a group of multi-sectoral doctors, had been at the forefront modern medicine. Cleveland Clinic is one of the best hospitals in America. In the first 100 years, it has opened many facilities all over the world, and introduced many firsts. The vision of its founders still remains today, more than 100 years after the clinic's founding: to care for the life and health of others, while educating the people who serve. Tom Mihaljevic MD reviews in his annual speech the achievements and challenges of the last year. He shares with us his vision of the future healthcare in Cleveland Clinic.